The other effect of both apoA1 isoform transgenes on plasma lipoproteins was the highly significant decrease in non-HDL cholesterol seen in both sexes ( Fig 2C and 2D ), which was also observed previously [ 19 ].
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Oxidant resistant human apolipoprotein A-I functions similarly to the unmodified human isoform in delaying atherosclerosis progression and promoting atherosclerosis regression in hyperlipidemic mice.
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