Combination of pseudoephedrine and emodin ameliorates LPS-induced acute lung injury by regulating macrophage M1/M2 polarization through the VIP/cAMP/PKA pathway.

When pseudoephedrine or emodin were used alone or in combination therapy, the D/W ratio had an increasing trend as the drug concentrations increased, and the corresponding combined treatments had more obvious positive effects on pulmonary edema (Fig. 1 G).

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