Facioscapulohumeral dystrophy weakened sarcomeric contractility is mimicked in induced pluripotent stem cells-derived innervated muscle fibres.

J Cachexia Sarcopenia Muscle · 2022 · PMC8818656 · PMID 34859613

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highly significantno p-value reported

By measuring fibre shifting over time, we observed a marked and highly significant decrease in the length of contraction of individual muscle fibres with length of contraction in FSHD fibres being 61% to 36% of the length of contraction determined in control fibres ( P value <0.0001, Figure 5C ).

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