Contemporary Drug Treatment of Advanced Heart Failure with Reduced Ejection Fraction.

Consistently, an analysis focused on 2258 patients with severe HF, defined similarly to the HFA criteria, as with NYHA symptom class III to IV, LVEF ≤ 30%, and with a HF hospitalization within the previous 6 months enrolled in GALACTIC-HF, showed a highly significant treatment effect of omecamtiv mecarbil on the primary endpoint of cardiovascular death or HF hospitalizations (HR, 0.80; 95% CIs, 0.71–0.90) [ 18 ].

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