Common DNA methylation changes in biliary tract cancers identify subtypes with different immune characteristics and clinical outcomes.

BMC Med · 2022 · PMC8822710 · PMID 35130881

Europe PMC DOI

hedged sentence

0.1040

closest p · 2.1× alpha

0.1040

boldest claim

The sentences

borderline significanceP = 0.104not close (p > 0.1)

In addition, a large difference of OS with borderline significance was uncovered between the PD-L1 + / CD8A methyl-high and the PD-L1 + / CD8A methyl-low groups (HR = 4.96, 95% CI 0.59–41.75, P = 0.104, Fig. 6 E), indicating the differed prognostic effects of the PD-L1 elicited by immune attack and the one induced by the oncogenic pathway.

also in 7,017 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.