Chloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives.

J Exp Clin Cancer Res · 2022 · PMC8822754 · PMID 35135603

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highly significantno p-value reported

Regarding the efficacy of each compound, assessed comparing the maximal antiproliferative effect observed at 3 mM, all active biguanides (Q42, Q48, Q49, Q50, Q53 and Q54) caused a highly significant inhibition of GSC viability, showing efficacy ranging between − 71 and − 83%.

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