The C-terminal tail of α-synuclein protects against aggregate replication but is critical for oligomerization.

There is a weak trend for primary nucleation rates to fall with construct length (Fig. 2b ); more strikingly, we see a jump between two relatively constant levels in the rate of the secondary process (Fig. 2c ) between αSN130 and αSN125 (we attribute the low k n value of αSN115 to a fitting artifact in which a low k n value is compensated by a higher k - value).

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