Loss of SMAD4 Is Associated With Poor Tumor Immunogenicity and Reduced PD-L1 Expression in Pancreatic Cancer.

Front Oncol · 2022 · PMC8832494 · PMID 35155243

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highly significantno p-value reported

We next evaluated the comparative expression of several immune-associated genes within these groups and determined that patients with wild type SMAD4 had a highly significant increase in mRNA expression of the pan T-cell markers CD3E and CD3G ( Figures S1D, E ).

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