Second Cancers in Classical Hodgkin Lymphoma and Diffuse Large B-Cell Lymphoma: A Systematic Review by the Fondazione Italiana Linfomi.

These studies, while recording a positive trend of a lower incidence of second tumors after the introduction of a smaller radiation volume, such as IFRT, suffered from a lack of specific volumetric and dosimetric data regarding the RT treatment actually delivered and the volume of the organs at risk (OAR) irradiated.

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When analyzed in a multivariable analysis, there was a trend toward significance for radiation field volume, only for all-cause mortality, probably due to the small number of events within each treatment period.

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