Sphingosine Kinase-1 Is Overexpressed and Correlates with Hypoxia in Osteosarcoma: Relationship with Clinicopathological Parameters.

As shown in Table 4 , although the strength of linear correlation between SphK1 and GLUT-1 was weak, it was statistically extremely significant for all osteosarcomas ( p = 0.005 for percentage of stained cells and p = 0.001 for IRS score).

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Highly significant resistance to chemotherapies used in clinics including etoposide, cisplatin and doxorubicin have been reported in cellular models of osteosarcoma under hypoxic conditions [ 49 , 52 ].

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Similarly, in long-bone osteosarcomas, S1P 1 expression was associated with an increased risk of death HR = 1.29 (95% CI: 1.00–1.66) at the limit of significance (based on % of stained cells) with regard to overall survival.

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With regard to long bones, the expression of GLUT-1 (% of stained cells and IRS score) was, associated with an increased risk of death HR = 1.16 (95% CI: 0.98–1.38) and HR = 1.14 (95% CI: 1.00–1.29) with borderline significance (0.08 and 0.06, respectively).

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