Multi-Omics Profiling to Assess Signaling Changes upon VHL Restoration and Identify Putative VHL Substrates in Clear Cell Renal Cell Carcinoma Cell Lines.

We saw highly significant overlap of 63 proteins that corresponded to 132 peptides ( Figure 4 D, Supplementary Table S10 ), including well-characterized VHL targets such as HIF2α (EPAS1), FN1 and VHL itself [ 50 , 51 , 52 , 53 ].

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