Six-Minute Walk Distance Is a Useful Outcome Measure to Detect Motor Decline in Treated Late-Onset Pompe Disease Patients.

In contrast to LOPD patients, in controls, the mean 6MWD significantly increased after 6 and 18 months, from 661.3 m at baseline to 688.2 m after 6 months ( p < 0.045), to 680.2 m after 18 months ( p < 0.020), to 694.6 m after 24 months, which just failed to reach significance ( p = 0.054), corresponding to a mean amelioration of 33.3 m over 2 years ( Table 3 ; Figure 1 C).

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