Up-Regulation of Cyclooxygenase-2 (COX-2) Expression by Temozolomide (TMZ) in Human Glioblastoma (GBM) Cell Lines.

First of all, the data obtained show that NS398, alone or combined with TMZ, influenced, in a more or less significant way, just COX-2 + T98G cells, while no effect was detected in U251MG, confirming that the NS398 activity was closely associated with COX-2 inhibition.

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