Fisetin Deters Cell Proliferation, Induces Apoptosis, Alleviates Oxidative Stress and Inflammation in Human Cancer Cells, HeLa.

Int J Mol Sci · 2022 · PMC8835995 · PMID 35163629

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a decreasing trendno p-value reported

Fisetin Shows Early Apoptosis on HeLa Cells Annexin V/PI double staining on treated HeLa cells at 20, 30 and 50 μM for 48 h displayed an increase in the early and late apoptotic cells, whereas the percentage of live cells showed a decreasing trend.

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an increasing trendno p-value reported

Nuclear morphological alteration followed by fisetin treatment (20, 30 and 50 μM) of HeLa cells through DAPI staining showed characteristics of apoptotic nuclear morphology that proves the apoptosis-inducing property of fisetin, which showed an increasing trend both in the dose and time-dependent manner.

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