Usher Syndrome Belongs to the Genetic Diseases Associated with Radiosensitivity: Influence of the ATM Protein Kinase.

At 24 h post-irradiation, the USH1 fibroblasts showed systematically more γH2AX foci 24 h post-irradiation (GM03889: 1.2 ± 0.2, GM03854: 1.5 ± 0.4, and GM03891: 0.9 ± 0.1 γH2AX foci per cell) than the radioresistant controls (0 ± 0.5 γH2AX foci per cell); however, these differences were at the limit of significance ( p = 0.05) ( Figure 3 A,B).

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