MicroRNA-146a and microRNA-146b deficiency correlates with exacerbated disease activity, and their longitude increment relates to etanercept response in psoriasis patients.

Further subgroup analyses disclosed that in PASI75 responders, miR‐146a expression also showed an elevated trend throughout these four time points ( p < 0.001) (Figure 3B ); while in non‐PASI75 responders, the increasing trend of miR‐146a expression was not significant throughout these four time points ( p = 0.124) (Figure 3C ).

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1 , 15 , 19 Besides, miR‐146a was positively correlated with miR‐146b in psoriasis patients and disease controls, while the correlation of miR‐146a and miR‐146b displayed a positive trend in health controls.

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