Importantly, our study did demonstrate an increasing trend in the use of antibiotics related to first episodes of OM during the study period.
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The Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Otitis Media-Related Antibiotic Use Among Young Children in Tennessee, USA.
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We observed 494.3 monthly OM-related antibiotic fills per 1000 PY in the post-PCV13 period compared to 458.6 during the pre-PCV13 period, though a nonsignificant trend decline was observed between periods (trend difference, –3.02 [95% confidence interval {CI}, –8.74 to 2.70]) ( Figure 1 ).