Novel epigenetic network biomarkers for early detection of esophageal cancer.

Clin Epigenetics · 2022 · PMC8845366 · PMID 35164838

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

marginally significantP = 0.06so close (0.05 < p ≤ 0.1)

Although these associations were partly driven by the increased epithelial fraction, the associations with EAC-status remained marginally significant under a linear regression model where we adjusted for the epithelial content (Cohort-1: t = 1.9, P = 0.06; Cohort-2: t = 1.8, P = 0.09).

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highly significantno p-value reported

However, in each of the 4 patients the calculated FEM-score of the CTNND2 module was higher in the epithelial cells from BE compared to the adjacent normal squamous epithelium, and results were highly significant when merging the cells from all 4 patients together (Fig. 4 c).

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