Effect of Ultraviolet B Irradiation on Melanin Content Accompanied by the Activation of p62/GATA4-Mediated Premature Senescence in HaCaT Cells.

21 - 23 The expression change of SASP factors was detected after UVB irradiation, the results showed that the expressions of TNF-α, VEGF-A, and IL-8 mRNA had an increasing trend compared with the control group ( Figure 4 ), especially the expressions of TNF-α mRNA increased significantly ( t = 7.67, P < .05) ( Figure 4A ), and the level of TNF-α protein also increased significantly compared with control group ( Figure 4D ) at 72 h after UVB irradiation.

also in 60,069 other papers