Pharmacological modulation of Kv1.3 potassium channel selectively triggers pathological B lymphocyte apoptosis in vivo in a genetic CLL model.

Notably, in the peripheral blood the effect of PAPTP was highly significant as it caused an almost six-fold decrease of CLL B cells (Fig. 3 a) ( n = 7, pre-therapy: 9562 ± 3494 CD5 + CD19 + /mm 3 blood; PAPTP: 1665 ± 345 CD5 + CD19 + /mm 3 ).

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