From hair to liver: emerging application of hair follicle mesenchymal stem cell transplantation reverses liver cirrhosis by blocking the TGF-β/Smad signaling pathway to inhibit pathological HSC activation.

PeerJ · 2022 · PMC8855721 · PMID 35186473

Europe PMC DOI

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The sentences

an increasing trendP < 0.05actually significant

The expression of α-SMA, a marker of HSC activation, showed an increasing trend in the model group, which was reversed by HF-MSC treatment ( P < 0.05) ( Fig. 6 ).

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a decreasing trendno p-value reported

In addition, in contrast to that in the LC group, the α-SMA expression showed a decreasing trend in the treatment group in vitro and in vivo , indicating that the pathological activation of hepatic stellate cells (HSCs) was inhibited by HF-MSC treatment.

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