The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation.

With the exception of IL-17A, whose increase in the presence of sPLA 2 -IIA almost reached statistical significance ( P = 0.0873) ( Supplemental Figure 4 ) and was confirmed in a larger set of animals ( Figure 3F ), no modulation was measured in the concentration of the other 17 quantified cytokines, namely GM-CSF, IFN-γ, IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-10, IL-12p70, IL-13, CXCL1, CXCL5, MCP-1, MIP-2, and TNF-α.

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