Avoiding data loss: Synthetic MRIs generated from diffusion imaging can replace corrupted structural acquisitions for freesurfer-seeded tractography.

In other datasets, all other comparisons with the first in-vivo pipeline showed differences that were significant, or bordered on significance (HCP-M in-vivo repeat, p = 0.01; HCP-M synthetic, p = 0.06; Hospital synthetic, p = 0.08), but these median differences (0.33%, 0.24%, and 0.78% respectively) were again well below inter-group and longitudinal differences of clinical or scientific significance [E.g. 4 , 48 ]. 4.3 Comparison of Freesurfer labels Table 4 shows generalised Dice similarity coefficients for 70 cortical grey matter labels, or 16 deep grey-matter labels.

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