PIK3CA co-occurring mutations and copy-number gain in hormone receptor positive and HER2 negative breast cancer.

NPJ Breast Cancer · 2022 · PMC8857304 · PMID 35181669

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borderline significantno p-value reported

In all datasets we aimed to establish if there were genomic mutations enriched in PIK3CA -mut/gain tumors compared to PIK3CA -mut/neut and found that TP53 mutations were indeed significantly enriched ( q value < 0.05) in primary PIK3CA -mut/gain BC samples from METABRIC and MSK-2018 while only a borderline significant association was found in TCGA ( q value = 0.06).

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