Lessons learned and lessons missed: impact of the coronavirus disease 2019 (COVID-19) pandemic on all-cause mortality in 40 industrialised countries and US states prior to mass vaccination.

Even with high vaccine coverage, some adherence to other measures may be needed when the number of infections rises, because vaccine efficacy is less than 100%, especially against new variants of SARS-CoV-2 81 , and because the morbidity and longer-term health morbidity impacts of infection may be significant.

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