Emvododstat, a Potent Dihydroorotate Dehydrogenase Inhibitor, Is Effective in Preclinical Models of Acute Myeloid Leukemia.

Interestingly, as shown in Figure 2D , baseline levels of uridine did correlate with sensitivity (although the correlation did not quite reach statistical significance) suggesting that cell lines that were less sensitive may have higher levels of metabolites attributed to the salvage pathway.

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