Chondroitin sulfate-functionalized lipid nanoreservoirs: a novel cartilage-targeting approach for intra-articular delivery of cassic acid for osteoarthritis treatment.

Drug Deliv · 2022 · PMC8865121 · PMID 35188017

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highly significantno p-value reported

CHS-CA-NRs showed a highly significant increase in fluorescence intensity (210 ± 40 and 170 ± 25 for healthy and arthritic groups, respectively) compared to CA suspension (55 ± 10 and 40 ± 7 for healthy and arthritic groups, respectively) ( p ˂ .001) after day 1 ( Figure 3(b) ).

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