Pharmacokinetics and Pharmacodynamics of Key Components of a Standardized <i>Centella asiatica</i> Product in Cognitively Impaired Older Adults: A Phase 1, Double-Blind, Randomized Clinical Trial.

Antioxidants (Basel) · 2022 · PMC8868383 · PMID 35204098

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nearly reached significanceno p-value reported

Significantly lower ( p < 0.05) mean baseline values were observed at the two study visits for ferulic acid ( p < 0.001), isoferulic acid ( p = 0.01), and dihydroferulic acid ( p = 0.02), while the lower values for caffeic acid ( p = 0.08) and 3-(3-hydroxyphenyl)propionic acid ( p = 0.06) nearly reached significance, thereby confirming the washout of the analytes of interest with the 48 h low phytochemical diet. 3.2.3.

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