Systemic Administration of the TLR7/8 Agonist Resiquimod (R848) to Mice Is Associated with Transient, In Vivo-Detectable Brain Swelling.

At scan 3, the three-group ANOVA was marginally significant (F 2,22 = 3.1, p = 0.07): the 100 μg R848-treated mice had higher temperatures than the control animals ( p = 0.02) but were not different from the 50 μg R848 treated animals ( p = 0.24); temperature did not distinguish the 50 μg R848-treated and control mice at the third scan ( p = 0.25). 3.2.

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