Peripheral inflammation is associated with micro-structural and functional connectivity changes in depression-related brain networks.

This demonstrated a highly significant difference in the distribution of PD (right-shifted) in high CRP (> 3 mg/L) versus low CRP (< 3 mg/L) depression cases (Kolmogorov-Smirnov test, P < 6.4 × 10 −7 ) and between high CRP depresssed cases and controls (Fig. 1A ).

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