Patterns of brain asymmetry associated with polygenic risks for autism and schizophrenia implicate language and executive functions but not brain masculinization.

In contrast, ASD polygenic risk was significantly and positively associated with college or university qualifications, and also showed a positive trend of association with fluid intelligence ( β = 0.04, uncorrected p = 8.78 × 10 −4 ), although the latter did not meet FDR correction at 0.05.

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Regardless, when adjusting for sex, the multivariate associations of both polygenic risks with brain asymmetries were highly significant and not associated with either a more male-like or more female-like average pattern.

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