Considering the large amount of data, we used false discovery rate (FDR) correction on p -value and considered associations with p -value after FDR correction < 0.05 as significant, and highly significant with p -value after FDR correction < 0.01 (Table 4 , Supplementary Table 2 ).
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A reassessment of Jackson's checklist and identification of two Down syndrome sub-phenotypes.
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