Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression.

Am J Hum Genet · 2022 · PMC8874228 · PMID 35077669

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Pathway enrichment analysis identified that the cytoskeleton-regulation-related pathways were significant in the MUT35 and MUT70 midbrain organoids in all three respective cell types, while LRRK2-PD-related pathway occurred to be highly significant in NBs in vitro .

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