Synthesis and Antimicrobial, Anticancer and Anti-Oxidant Activities of Novel 2,3-Dihydropyrido[2,3-d]pyrimidine-4-one and Pyrrolo[2,1-b][1,3]benzothiazole Derivatives via Microwave-Assisted Synthesis.

Moreover, the 1,3-benzothiazole nucleus is a highly significant scaffold in the drug design, due to important pharmacological and medicinal activities, such as being antiviral [ 19 ], antituberculosis [ 20 ], an identifier of selective CB2 receptor ligands [ 21 ], antitumor [ 22 , 23 , 24 ], antimicrobial [ 25 , 26 , 27 ], anticonvulsant [ 28 ], a schistosome BCL-2 inhibitor [ 29 ], antidiabetic [ 30 ], antioxidant [ 31 ], an anti-Alzheimer drug [ 32 ] and a urease inhibitor [ 33 ] among the heterocyclic compounds containing a pyrimidine and benzothiazole nucleus that exhibits biological activity [ 34 , 35 , 36 ] ( Figure 1 ).

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