In Patients with Severe COVID-19, the Profound Decrease in the Peripheral Blood T-Cell Subsets Is Correlated with an Increase of QuantiFERON-TB Gold Plus Indeterminate Rates and Reflecting a Reduced Interferon-Gamma Production.

Furthermore, a decreasing trend of IFN-γ production in the Mitogen-Nil condition was found proceeding from patients who did not need oxygen therapy (AA, 9.63 IU/mL), through patients with VMK (2.68 IU/mL), NRM (1.90 IU/mL) and NIV (1.92 IU/mL), to patients who underwent OTI (0.97 IU/mL) for mechanical ventilation ( p < 0.001).

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