Influence of tumor mutational burden, inflammatory gene expression profile, and PD-L1 expression on response to pembrolizumab in head and neck squamous cell carcinoma.

J Immunother Cancer · 2022 · PMC8883256 · PMID 35217573

Europe PMC DOI

hedged sentence

0.0550

closest p · 1.1× alpha

0.0550

boldest claim

The sentences

a positive trendp = 0.0550so close (0.05 < p ≤ 0.1)

Results TMB, clonality-weighted TMB, and Tcell inf GEP were significantly associated with objective response (p = 0.0276, p = 0.0201, and p = 0.006, respectively), and a positive trend was observed between NL and PD-L1 CPS and clinical response (p = 0.0550 and p = 0.0682, respectively).

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