<i>α</i>-Ketoglutarate Improves Meiotic Maturation of Porcine Oocytes and Promotes the Development of PA Embryos, Potentially by Reducing Oxidative Stress through the Nrf2 Pathway.

We observed that high concentrations of α -KG could reduce the PBE rate, while 100 μ M α -KG could significantly decrease the PBE rate of oocytes (S-table 1 ), and 10 and 20 μ M α -KG could significantly increase the PBE rate of oocytes (S-table 1 ), and the difference in the 20 μ M group was extremely significant (Con vs. 20 μ M: 64.7% ± 1.20% vs. 76.83% ± 1.05%, P < 0.001) ( Figure 1(b) ). 3.2.

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