In China, the incidence and mortality of CRC have been witnessed with an increasing trend of 12.8 in 2003 to 16.8 per 100,000 in 2011 and 5.9 in 2003 to 7.8 per 100,000 in 2011, respectively [ 3 ].
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The methylation of SDC2 and TFPI2 defined three methylator phenotypes of colorectal cancer.
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