An increasing trend of IFNα2, IFNγ and IL-1 family cytokines (IL-33, IL-1β and IL-18) and an unexpected decrease in MCP-1 secretion was observed in ALS MDMi compared to HC (Additional file 1 : Fig.
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ALS monocyte-derived microglia-like cells reveal cytoplasmic TDP-43 accumulation, DNA damage, and cell-specific impairment of phagocytosis associated with disease progression.
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