Loss of histone methyltransferase SETD1B in oogenesis results in the redistribution of genomic histone 3 lysine 4 trimethylation.

Because MLL2 is highly dependent on underlying CpG content ( 40 ), we then examined sequence composition in the regions that gain H3K4me3 in the Setd1b cKO and found a highly significant enrichment for CpG content compared to a random set of regions (Figure 1D and Supplementary Figure S1E ).

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