Barely Significant
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miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review.

Mol Ther Nucleic Acids · 2022 · PMC8891816 · PMID 35282417

Europe PMCDOI
1
hedged sentence
0.0863
closest p · 1.7× alpha
0.0863
boldest claim

The sentences

almost significantlyp = 0.0863so close (0.05 < p ≤ 0.1)
miR-221-3p overexpression was almost significantly associated with time to metastasis (p = 0.0863) and with poor prognosis (p = 0.0074). 248 Different studies explored the upregulation of miR-221 to influence cell proliferation, migration, and invasion, by different mediators such as suppressing PTEN and so activating PI3K/Akt pathway, 249 or suppressing FBXW11 through Wnt pathway activation, 250 or inducing cisplatin resistance through downregulation of the tumor-suppressor gene PPP2R2A .

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