Visual pigment-deficient cones survive and mediate visual signaling despite the lack of outer segments.

Proc Natl Acad Sci U S A · 2022 · PMC8892328 · PMID 35197287

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may not be significantno p-value reported

Although it has been demonstrated that gap junctions mediate bystander cell death in the retina ( 38 ), eliminating Cx36 in the retinal degeneration-1 (rd1) mouse model did not slow down secondary cone loss ( 39 ), indicating that the rod–cone coupling role in the secondary death of cones may not be significant or required.

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