Additionally, when we examined the three-year protection from only clade-shifted A/H3N2 3c2.a viruses post-2014, we found borderline significant protection (aOR: 0.55, CI: 0.30–1.03), indicating that while protection from A/H3N2 among children generally lasts for a period of 2 years this protection may last up to 3 years if there is less antigenic drift in the virus, and reinforcing the joint impact of time and antigenic distance on protection from influenza.
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Homotypic protection against influenza in a pediatric cohort in Managua, Nicaragua.
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