Astrocytic junctional adhesion molecule-A regulates T-cell entry past the glia limitans to promote central nervous system autoimmune attack.

CKO mice also demonstrated an increasing trend not reaching statistical significance in the number of CD4 + immune cells within lesions compared with the WT group ( Fig. 4C and D ).

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Lesion size after AdIL-1 injection, measured as area of neuronal loss, showed a decreasing trend not reaching statistical significance in mGFAP:CreJAM-A fl/fl (CKO) mice compared with JAM-A flfl (WT) mice ( Fig. 4A and B ).

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