Brain metastases, patterns of intracranial progression, and the clinical value of upfront cranial radiotherapy in patients with metastatic non-small cell lung cancer treated with PD-1/PD-L1 inhibitors.

Transl Lung Cancer Res · 2022 · PMC8902084 · PMID 35280308

Europe PMC DOI

hedged sentence

0.0550

closest p · 1.1× alpha

0.0550

boldest claim

The sentences

borderline significanceP=0.055so close (0.05 < p ≤ 0.1)

For patients with BMs at baseline, a significant association was uncovered between uCRT and a favorable survival outcome on univariate analysis (HR: 0.50, 95% CI: 0.25–0.99, P=0.045), and this association retained borderline significance on multivariate analysis (HR =0.55, 95% CI: 0.28–1.10, P=0.055, Table S5 ).

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