8 , 19 , 22 , 23 One study concluded that good adherence may not be significant for achieving viral re-suppression but it is significant for preventing viral non-suppression and virological rebound. 20 Furthermore, patients who participated in drug holidays (defined as a >10% difference between overall adherence rate versus 60-day refills calculated adherence rates) versus patients with persistent non-adherence were more likely to develop LLV.
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