Barely Significant
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High Mobility Group Box 1: Biological Functions and Relevance in Oxidative Stress Related Chronic Diseases.

Cells · 2022 · PMC8909428 · PMID 35269471

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an increasing trendno p-value reported
The data reveal an increasing trend of papers in this field, with the peak of publications having been reached in 2019, with 133 records found.

also in 63,971 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.