Importantly, however, treatment with the synergistic drug combination MBV + LDC4297 induced a drastic and highly significant reduction in CDK7 intensity, almost to mock-infected level (101% ± 3%, green square).
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Cyclin-Dependent Kinases (CDKs) and the Human Cytomegalovirus-Encoded CDK Ortholog pUL97 Represent Highly Attractive Targets for Synergistic Drug Combinations.
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