An Update on Synthesis of Coumarin Sulfonamides as Enzyme Inhibitors and Anticancer Agents.

The methyl-substituted thiazole-based coumarin sulfonamide 109b ( Figure 19 ) was the most active derivative, which exhibited highly significant anticancer therapeutic potential against MCF7 cell line with IC 50 value 10.62 ± 1.35 ( Table 17 ), by comparing it with standard compound doxorubicin drug having an IC 50 value 3.18 ± 0.32 μM [ 81 ]. 3.6.

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