C-H Insertion via Ruthenium Catalyzed <i>gem</i>-Hydrogenation of 1,3-Enynes.

Since labeled compounds are of eminent importance in medicinal chemistry and elsewhere, this facile, flexible, and if necessary, scalable entry is arguably significant. 44 , 45 CAM struggles when it comes to using nonterminal alkynes, since delivery of the primary carbene derived from the diazo derivative is then typically regiounselective; 15 , 17 , 18 once again, the new gem -hydrogenative approach has no problem in providing access to such products as amply illustrated by Scheme 4 B.

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